Neural substrates of subcortical aphasia in subacute stroke: Voxel-based lesion symptom mapping study

Subcortical aphasia develops as a result of damage to subcortical brain areas without loss cortical functions. Although earlier voxel-based lesion-symptom mapping (VLSM) studies have shown possible neural correlates for aphasia, it remains be clarified which regions are associated with aphasia. The aim this study was investigate the substrates in patients stroke using VLSM and atlas-based analyses explore involvement white matter tracts structures. Fifty subacute were retrospectively enrolled: 24 26 We performed patients' fluid-attenuated inversion recovery images found that left perisylvian matter, fronto-occipital fasciculus, uncinate forceps minor significantly more greatly affected than non-aphasia group. anterior thalamic radiation, cingulum (cingulate gyrus), superior longitudinal fasciculus also showed higher group (marginal significance). Among regions, caudate putamen involved Our findings confirm language processing one integrated sensory-motor processes occur region around sylvian fissure. analysis approach can used complement analyses.